Connect with us ! Google+ LinkedIn Pinterest YouTube

Common Symptoms of Celiac Disease and Gluten Sensitivity

Share on Facebook1Tweet about this on TwitterShare on LinkedIn12Share on Google+0Pin on Pinterest1Email this to someone

Since the month of May is Celiac Awareness month, I thought it appropriate to do a blog post on the subject of gluten sensitivity.  Celiac Disease is classed as an autoimmune condition of the small intestine because of its reaction to gluten.  Symptoms of Celiac can affect almost any area of the body with common symptoms being;

  • Abdominal cramping and bloating
  • Diarrhea with pale, loose, greasy stools
  • Fatigue
  • Weight loss
  • Malabsorption issues with iron, B12, calcium, vitamin D and K
  • Mouth ulcers
  • Skin concerns – itchy, sore, red areas
  • Other autoimmune conditions including; Type 1 diabetes, hypothyroid, biliary cirrhosis, colitis
  • Neurological symptoms ranging anywhere from headache, migraine to neuropathy, autism and schizophrenia

It can be challenging to get a proper diagnosis, but conventional testing will look at blood tests for specific antibodies including:

  • AGA (antigliadin antibodies)-IgA
  • AGA-IgG
  • tTG (anti-tissue transglutaminase)-IgA
  • EMA (anti-endomysial antibodies)-IgA
  • Total serum IgA

In addition to these tests, a biopsy of the small intestinal tissues may be performed as well as genetic testing looking for specific genes known as HLA-DQ2 and HLA-DQ8.  The blood tests can produce false negatives, yet the biopsy test is more precise but also much more invasive, and the gene tests can show that you have a genetic predisposition for the disease but not Celiac disease itself.

In addition, the blood tests that indicate a positive for Celiac show an immune reaction to a specific gluten fraction known as alpha gliadin, and a specific enzyme known as tTG-2 (a transglutaminase enzyme).  There are however several other fractions of gliadins in gluten (beta, gamma, and omega) and additional components like glutenin, wheat germ agglutinin, deamidated gliadin and transglutaminase type 3 and type 6.  In short, there are several other factors that one may react to, which brings us to the topic of Non Celiac Gluten Sensitivity (NCGS for short).

For stats on both Celiac and NCGS I’ll refer you to a previous AOR blog post by Dr. Mainland here. This is a great article showing just how much both of these are on the rise. If you look in your local grocery store these days, it is clear that the gluten free movement is significantly on the rise.

NCGS is really a grey area in the medical community with no clearly defined diagnostic test.  Symptoms for NCGS can affect virtually any area of the body adversely and may not present with any associated gastrointestinal symptoms at all. Symptoms may involve poor immune status, eczema/psoriasis, asthma, arthritis, migraine, osteoporosis, thyroid imbalance, other hormonal imbalances, diabetes or AD/HD. This list of potential negative effects as a result of consuming gluten goes on and on.

There are some forward thinking laboratories that have begun to offer tests to look at the other fractions of gluten and antibodies associated with NCGS conditions.  Antibodies such as IgE, IgG, sIgA and gluten peptide testing can all reveal insights into the levels of gluten sensitivity in each individual.  These tests are usually not performed by your GP and are more often found being done by a naturopathic doctor or other integrated practitioner.

The gold standard for assessment however, continues to be the elimination diet. This involves completely removing gluten from the diet for a period of at least 30 days, gluten freeand then slowly adding it back in after that. If symptoms improve during the elimination period, and return when gluten is reintroduced, a diagnosis of NCGS can be made.  It can be difficult to achieve both for adults and children alike since wheat is a major component of the North American diet, and hidden in many food items as well.  That being said, it is clinically very conclusive.

Images by © 2014 LoloStock and © 2014 Monkey Business via DollarPhotoClub

Sources

Di Sabatino A, Corazza GR (April 2009). “Coeliac disease”. Lancet 373 (9673): 1480–93. doi:10.1016/S0140-6736(09)60254

Presutti RJ, Cangemi JR, Cassidy HD, Hill DA (2007). “Celiac disease”. Am Fam Physician 76 (12): 1795–802

National Institute for Health and Clinical Excellence. Clinical guideline 86: Recognition and assessment of coeliac disease. London, 2009

Schuppan D, Junker Y, Barisani D (December 2009). “Celiac disease: from pathogenesis to novel therapies”. Gastroenterology 137 (6): 1912–33.

van der Windt DA, Jellema P, Mulder CJ, Kneepkens CM, van der Horst HE (2010). “Diagnostic testing for celiac disease among patients with abdominal symptoms: a systematic review”. JAMA 303 (17): 1738–46.

Carroccio, A et al. Non-celiac wheat sensitivity diagnosed by double-blind placebo-controlled challenge: exploring a new clinical entity. Am J Gastroenterol. 2012 Dec;107(12):1898-906.

 

Leave a Reply

Your email address will not be published. Required fields are marked *

Retype the CAPTCHA code from the image
Change the CAPTCHA codeSpeak the CAPTCHA code
 

Protected with IP Blacklist CloudIP Blacklist Cloud

JOIN US NOW
Purus sed vel ultricies, lorem rhoncus. Augue hac, adipiscing risus, sed ac? Pid nunc dignissim, non, ac parturient sociis enim.
Your Information will never be shared with any third party.
SUBSCRIBE TO NEWSLETTER
All rights reserved © Company Name, 2014
Dolor aliquet augue augue sit magnis, magna aenean aenean et! Et tempor, facilisis cursus turpis tempor odio, cursus montes ac turpis. Ultrices! Massa integer augue ridiculus adipiscing, massa cras pid. Turpis placerat scelerisque, vut odio mus non, mattis porttitor, nunc odio, turpis tortor sit? Pid amet, sed facilisis.
  • Goblinus globalus fantumo tandempo
  • Scelerisque cursus dignissim donus
  • Montes vutario lacus quis arcupolisio
  • Leftomato denitro oculus tepircos den
  • Spiratio dodenus christmas popupius
  • Afrenius globalus spiritum tandempo
  • Fitatos vutario lacus quis arcup delis
Here's $3 Off
Apply $3 off at checkout to any AOR product purchase. Just send your name and email and we'll email you your coupon.
Your Information will never be shared with any third party.
JOIN US NOW
Stay ahead of the curve with the latest AOR news, industry trends, and new product launches.
Your Information will never be shared with any third party.
Do you want massive traffic?
Dignissim enim porta aliquam nisi pellentesque. Pulvinar rhoncus magnis turpis sit odio pid pulvinar mattis integer aliquam!
  • Goblinus globalus fantumo tubus dia montes
  • Scelerisque cursus dignissim lopatico vutario
  • Montes vutario lacus quis preambul den lacus
  • Leftomato denitro oculus softam lorum quis
  • Spiratio dodenus christmas gulleria tix digit
  • Dualo fitemus lacus quis preambul pat turtulis
* we never share your e-mail with third parties.
JOIN US TODAY
For the latest:
AOR is committed to your privacy, your information will not be shared with any third party. You may unsubscribe at any time.
COMPANY UPDATES
INDUSTRY TRENDS
PRODUCT LAUNCHES
Nutrition Education
AOR is committed to your privacy, your information will not be shared with any third party. You may unsubscribe at any time.
Science-based facts from our team of top medical experts delivered right to your inbox!
Health Basics
Fitness Advice
JOIGNEZ-NOUS AUJOURD'HUI
Les dernières nouvelles:
AOR s’engage à protéger la confidentialité de vos données. Elles ne seront pas partagées avec des tiers. Vous pouvez vous désabonner à tout moment
MISE À JOUR
TENDANCES DE L'INDUSTRIE
LANCEMENTS DE PRODUITS
JOIN US TODAY
For the latest:
AOR is committed to your privacy, your information will not be shared with any third party. You may unsubscribe at any time.
SPECIAL RETAILER OFFERS
JOIN US TODAY
For the latest:
AOR is committed to your privacy, your information will not be shared with any third party. You may unsubscribe at any time.
MONTHLY PRICE LIST
JOIN US TODAY
For the latest:
AOR is committed to your privacy, your information will not be shared with any third party. You may unsubscribe at any time.
PRODUCT LAUNCHES